Sealing sterile packaging

The purpose of hermetic sealing is to maintain the sterility of the content of the packages after the preparation, sterilization, storage and distribution processes, and both prior to and at the moment of use. The sealing of the package should be very secure and avoid any type of opening. Paper bags will be folded twice and then sealed with adhesive tape, which will be applied vertically at the closure. Boxes (metal or plastic) should not be sealed with any type of adhesive tape. The sealing should permit later opening that is aseptic and allows the use of an easy technique that prevents dropping or breakage of the material. Sealing can be carried out according to the following techniques:

  • With adhesive tapes
  • Bundled with strings or cotton thread
  • Manual folding
  • Heat-sealed

Do not use the following for sealing:

  • Clasps
  • Pins
  • Other sharp elements

All of these elements could break the package.

Materials and machines used in heat-sealing

  • Mixed or simple packaging with polyethylene
  • Adhesive tape with an external chemical control
  • Internal chemical indicator or integrator
  • Machine sealer

Practical recommendations

Observe the integrity of the package by looking for wrinkles and burned areas.

The sealer should be regulated at an adequate temperature level for effective sealing.

When carrying out the sealing process, allow a minimum margin of 3 cm. from the edges of the package in order to permit later aseptic opening of the package.

Sealing of paper and folios (film) made of plastic or polyethylene should guarantee the hermetic seal of the packaging. There are two types of machines for sealing materials for sterilization: manual and automatic.

Monday, October 30, 2023


Sterilization manual for health centers. Silvia I. Acosta-Gnass,Valeska de.

Please Check out file at the following link

Techniques or procedures for preparing sterile packages

Sterile Packaging models

Sterile Packaging techniques

Sterile Packaging selection and evaluation

Types of materials used and instructions for use